Senior Clinical Data Manager - South Africa (Home-based) - FSP

When our values align, there's no limit to what we can achieve. At Parexel, we all share the same goal - to improve the world's health.

From clinical trials to regulatory, consulting, and market access, every clinical development solution we provide is underpinned by something special - a deep conviction in what we do.Each of us, no matter what we do at Parexel, contributes to the development of a therapy that ultimately will benefit a patient. We take our work personally, we do it with empathy and we're committed to making a difference.About ParexelParexel is a leading global clinical development partner delivering insights-driven clinical and consulting solutions to the life sciences industry.

With 22,000+ employees worldwide, we partner with biopharmaceutical companies and research sites to design and deliver patient-focused clinical trials that broaden access and make research a care option for anyone, anywhere.We work with focus, agility, and shared purpose, moving with urgency to address patient needs and accelerate the delivery of new therapies. We embrace bold thinking, adapt quickly to change, and continually raise the bar for the speed and quality of clinical research.

We are expanding our team and seeking talented individuals to help drive industry-leading innovation, With Heart®.About the RoleWe are seeking a Senior Clinical Data Manager to join our team in South Africa in a permanent, full-time capacity.As a Senior Clinical Data Manager, you will play a critical role in supporting global commercial and development programs by leading clinical data management activities across Phase 1-4 studies.

This position is central to ensuring the quality, integrity, and reliability of clinical trial data that support the development of innovative therapies for patients worldwide.You will serve as a key data management leader within cross-functional study teams, driving the planning, execution, and oversight of data management deliverables throughout the clinical trial lifecycle. Responsibilities include leading study-level data management activities, collaborating with internal stakeholders and external vendors, supporting electronic data capture system development and validation, overseeing database lock activities, and ensuring compliance with regulatory requirements and industry standards.You'll join a fast-paced, growth-oriented environment where your expertise will directly influence study outcomes, operational excellence, and the successful delivery of clinical research programs.

With opportunities to work across global studies and collaborate with experienced clinical development professionals, this role offers a meaningful path for continued professional growth and leadership within clinical data management.Key ResponsibilitiesLead large clinical studies or a series of related studies with minimal guidanceRepresent Data Management on cross-functional clinical trial working groups for assigned studiesOversee and monitor data management activities performed by CROs and external vendors while building effective working relationshipsReview clinical protocols and provide leadership on data capture strategy, eCRF design, and data collection requirementsCollaborate with CRAs, programmers, study managers, statisticians, and other stakeholders to develop annotated eCRFs and completion guidelinesLead the development of data edit check specifications, data listings, and study-level data management plansCoordinate the design, testing, and implementation of Electronic Data Capture systems and resolve system-related issuesReview and provide feedback on study documentation, including monitoring plans, statistical analysis plans, and vendor specificationsConduct data reconciliations, including Serious Adverse Event reconciliation and external data source reconciliation activitiesLead database upgrades, migrations, user acceptance testing, database freeze activities, and database locks in accordance with company proceduresMaintain study workbooks, data management files, and study documentationMentor and train data management team members while contributing to the development of SOPs, work instructions, and process improvementsParticipate in team meetings and contribute expertise that supports study and organizational objectivesCandidate ProfileYou’ll thrive in this role if you bring:Strengths in clinical data management, project leadership, vendor oversight, and cross-functional collaborationExperience working within pharmaceutical, biotechnology, clinical research, or other FDA-regulated environmentsThe ability to manage multiple priorities while maintaining exceptional attention to detail and data qualityStrong communication skills and the confidence to collaborate effectively across internal teams and external partnersComfort working with Electronic Data Capture systems, data management technologies, clinical databases, and study documentation processesA commitment to delivering high-quality clinical data that supports informed decision-making and advances patient careRequired QualificationsBA/BS degree, preferably in a scientific or healthcare-related fieldAt least seven years of experience in Data Management within the pharmaceutical or biotechnology industry, or equivalent experience in an FDA-regulated environment, including study lead experienceKnowledge of ICH-GCP, FDA guidance, CDISC standards, GCDMP, 21 CFR Part 11, MedDRA, WHO Drug Dictionaries, and clinical trial processesExperience with Electronic Data Capture systems and clinical data management technologiesStrong project management, organization, communication, problem-solving, and multitasking skillsProven ability to support Phase 1-4 clinical studies and work effectively with vendors and cross-functional teamsFamiliarity with database upgrades, migrations, user acceptance testing, and advanced data management processesStrong English written and verbal communication skillsPreferred QualificationsScientific or healthcare-related educational backgroundExperience within Oncology or CNS therapeutic areasExperience supporting Phase III pivotal clinical studiesExperience training internal and external study team members on EDC systems and data management proceduresBenefits and CompensationMedical Aid ContributionGap CoverLife AssuranceProvident Fund (8%)13th ChequeIf this job doesn’t sound like the next step in your career, but perhaps you know of someone who’d be a perfect fit, send them the link to apply!We believe in flexibility, growth, and creating space for people to do their best work.

Join us and be part of a team where your contributions help shape the future of clinical research.